FLAM-seq: full-length mRNA sequencing reveals principles of poly(A) tail length control
نویسندگان
چکیده
منابع مشابه
Full-length mRNA sequencing uncovers a widespread coupling between transcription and mRNA processing
The multifaceted control of gene expression requires tight coordination of regulatory mechanisms at transcriptional and post-transcriptional level. Here, we studied the interdependence of transcription, splicing and polyadenylation events on single mRNA molecules by full-length mRNA sequencing. In MCF-7 breast cancer cells, we found 2,700 genes with interdependent alternative transcription, spl...
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ژورنال
عنوان ژورنال: Nature Methods
سال: 2019
ISSN: 1548-7091,1548-7105
DOI: 10.1038/s41592-019-0503-y